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  5. Tocris Bioscience™ IU1-47

Tocris Bioscience™ IU1-47

Catalog No. 644350
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50 mg
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Catalog No. Quantity
64-435-0 50 mg
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Catalog No. 64-435-0 Supplier Tocris Bioscience™ Supplier No. 6443/50
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Description

Potent USP14 inhibitor (IC50 = 60 nM)

IU1-47 is a potent USP14 inhibitor (IC50 = 60 nM). Demonstrates >30-fold selectivity for USP14 over USP5 (IsoT). Enhances degradation of proteasome substrates in vitro. Increases degradation of wild type and pathological tau in MEFs, primary neuronal cultures and human iPSC derived neurons.

Specifications

Chemical Name or Material 1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone
CAS 670270-31-2
Quantity 50 mg
Molecular Formula C19H23ClN2O
Formula Weight 330.85
Purity 98%
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