Invitrogen™ IVNS1ABP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA551926

Catalog No. PIPA551926

Description

Immunogen sequence: QDELIEKPMS PMQYARSGLG TAEMNGKLIA AGGYNREECL RTVECYNPHT DHWSFLAPMR TPRARFQMAV LMGQLYVVGG SNGHSDDLSC GEMYDSNIDD WIPVPELRTN RCNAGVCALN GKLYIVGGSD Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 95%.

IVNS1ABP is a protein coding gene involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro).; (Microbial infection) involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.

Specifications

• Antigen: IVNS1ABP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IVNS1ABP
• Gene Alias: 1190004M08Rik; 1700126I16Rik; AA960440; ARA3; aryl hydrocarbon receptor-associated 3; aryl hydrocarbon receptor-associated protein 3; FLARA3; HSPC068; influenza virus NS1A binding protein; influenza virus NS1A-binding protein; Influenza virus NS1A-binding protein homolog; Ivns1abp; kelch family protein Nd1; kelch family protein Nd1-L; kelch-like family member 39; Kelch-like protein 39; KIAA0850; KLHL39; mKIAA0850; NCX downstream gene 1; ND1; Nd1L; Nd1-L; ND1-L2; Nd1S; Nd1-S; NS1; NS-1; NS1-binding protein; NS1-binding protein homolog; Ns1bp; NS1-BP
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10625
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y6Y0
• Gene Symbols: IVNS1ABP
• Immunogen: Recombinant protein corresponding to Human IVNS1ABP. Recombinant protein control fragment (Product #RP-102250).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG