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IWP 2, Tocris Bioscience™ Catalog No.: 353310
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IWP 2, Tocris Bioscience™
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Catalog No. 353310
10 mg
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10 mg
50 mg
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Catalog No. 35-331-0

Supplier: R&D Systems 3533/10

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Description

PORCN inhibitor; inhibits Wnt processing and secretion

IWP 2 is a potent inhibitor of Wnt processing and secretion (IC50 = 27nM). IWP 2 inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. IWP 2 suppresses self-renewal in R1 embryonic stem cells and promotes cardiomyocyte differentiation from hPSCs.
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Chemical Identifiers

CAS 686770-61-6
Molecular Formula C22H18N4O2S3
Molecular Weight (g/mol) 466.59
MDL Number MFCD04457599
InChI Key WRKPZSMRWPJJDH-UHFFFAOYSA-N
Synonym iwp-2, iwp 2, n-6-methyl-2-benzothiazolyl-2-3,4,6,7-tetrahydro-4-oxo-3-phenylthieno 3,2-d pyrimidin-2-yl thio-acetamide, n-6-methylbenzo d thiazol-2-yl-2-4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno 3,2-d pyrimidin-2-yl thio acetamide, n-6-methyl-1,3-benzothiazol-2-yl-2-4-oxo-3-phenyl-6,7-dihydrothieno 3,2-d pyrimidin-2-yl sulfanyl acetamide, n-6-methylbenzo d thiazol-2-yl-2-4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno 3,2-d pyrimidin-2-ylthio acetamide, n-6-methyl-1,3-benzothiazol-2-yl-2-4-oxo-3-phenyl-6h,7h-thieno 3,2-d pyrimidin-2-yl sulfanyl acetamide, iwp hplc, 9xk, n-6-methyl-2-benzothiazolyl-2-3,4,6,7-tetrahydro-4-oxo-3-phenylthieno 3,2-d pyrimidin-2-yl thio
PubChem CID 2155128
IUPAC Name N-(6-methyl-1,3-benzothiazol-2-yl)-2-({4-oxo-3-phenyl-3H,4H,6H,7H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide
SMILES CC1=CC=C2N=C(NC(=O)CSC3=NC4=C(SCC4)C(=O)N3C3=CC=CC=C3)SC2=C1

Specifications

Quantity 10 mg
Formula Weight 466.6
Percent Purity >98%
Chemical Name or Material IWP 2

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Safety and Handling

Recommended Storage Store at +4°C
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