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  5. Tocris Bioscience™ IWP 2

Tocris Bioscience™ IWP 2
GREENER_CHOICE

Catalog No. 353310
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

PORCN inhibitor; inhibits Wnt processing and secretion

IWP 2 is a potent inhibitor of Wnt processing and secretion (IC50 = 27nM). IWP 2 inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. IWP 2 suppresses self-renewal in R1 embryonic stem cells and promotes cardiomyocyte differentiation from hPSCs.

Chemical Identifiers

CAS 686770-61-6
Molecular Formula C22H18N4O2S3

Specifications

Quantity 10 mg
Formula Weight 466.6
Purity >98%
Molecular Weight (g/mol) 466.59
Chemical Name or Material IWP 2

Safety and Handling

Recommended Storage Store at +4°C
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