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Invitrogen™ IWS1 Polyclonal Antibody
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Catalog No. PIPA563990
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100 μL
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PIPA563990 100 μL
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Catalog No. PIPA563990 Supplier Invitrogen™ Supplier No. PA563990
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: NEELPKPRIS DSESEDPPRN QASDSENEEL PKPRVSDSES EGPQKGPASD SETEDASRHK QKPESDDDSD RENKGEDTEM QND Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IWS1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene IWS1
Gene Accession No. Q96ST2
Gene Alias 1700069O15Rik; 3000008H23; AL117927; AW214353; interacts with Spt6; IWS1; IWS1 homolog; IWS1 homolog (S. cerevisiae); IWS1, SUPT6H interacting protein; Iws1l; IWS1-like protein; Protein IWS1 homolog; RGD1304762
Gene Symbols IWS1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human IWS1. Recombinant protein control fragment (Product #RP-104162).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55677
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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