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IWS1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 169431AP150UL

Encompass_Preferred

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Catalog No. 50-173-1280


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Description

Description

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
Specifications

Specifications

IWS1
Polyclonal
Unconjugated
IWS1
IWS1, IWS1 homolog (S. cerevisiae), IWS1 like protein, IWS1L, Protein IWS1 homolog
Rabbit
Antigen Affinity Chromatography
RUO
291705, 55677, 73473
-20°C
Liquid
Immunoprecipitation, Western Blot
0.25 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q3SWT4, Q8C1D8, Q96ST2
Iws1
IWS1 Fusion Protein Ag10554
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
SDS
Documents
Product Certifications
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