Invitrogen™ JAB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529872

Catalog No. PIPA529872

Description

Recommended positive controls: HeLa, mouse brain. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (99%), Xenopus laevis (99%), Pig (100%), Chicken (99%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the Signalosome, which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.

Specifications

• Antigen: JAB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cops5
• Gene Alias: 38 kDa Mov34 homolog; AI303502; COP9 (constitutive photomorphogenic) homolog, subunit 5; COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana); COP9 complex S5; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; COP9 signalosome subunit 5; Cops5; CSN5; JAB1; Jun activation domain-binding protein 1; Jun coactivator; Kic2; Kip1 C-terminus-interacting protein 2; MGC3149; Mov34; MOV-34; SGN5; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10987, 26754
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.35 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O35864, Q92905
• Gene Symbols: Cops5
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 198 of Human JAB1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG