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Invitrogen™ JAK1 Recombinant Rabbit Monoclonal Antibody (7Q1B2)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA542649
This item is not returnable.
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Description
Positive test controls include: Mouse lung. Immunogen sequence: GTLMDYKDDE GTSEEKKIKV ILKVLDPSHR DISLAFFEAA SMMRQVSHKH IVYLYGVCVR DVENIMVEEF VEGGPLDLFM HRKSDVLTTP WKFKVAKQLA S.
Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
Specifications
JAK1 | |
Recombinant Monoclonal | |
0.5 mg/mL | |
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P23458, P52332 | |
JAK1 | |
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human JAK1 (P23458). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
ELISA, Western Blot | |
7Q1B2 | |
Unconjugated | |
JAK1 | |
AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
16451, 3716, 84598 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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