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JAK2/JAK3 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA5106248
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PIPA5106248 100 μL
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Catalog No. PIPA5106248 Supplier Thermo Scientific Supplier No. PA5106248

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total JAK2/3.

Janus Activating Kinase 2 and 3 (JAK2/JAK3) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JAK2/JAK3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene JAK2
Gene Accession No. O60674, P52333, Q62120, Q62137, Q62689, Q63272
Gene Alias Breast-JAK3; fae; Fd17; JAK2; JAK-2; JAK3; JAK-3; JAK3_HUMAN; JAK3B; JAKL; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; JTK10; Leukocyte janus kinase; LJAK; L-JAK; RATJAK3; THCYT3; tyrosine-protein kinase JAK2; Tyrosine-protein kinase JAK3; wil
Gene Symbols JAK2, JAK3
Host Species Rabbit
Immunogen A synthesized peptide derived from human JAK2(Accession O60674), corresponding to amino acid residues Y940-V990.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16452, 16453, 24514, 25326, 3717, 3718
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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