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Invitrogen™ JAK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

$209.50 - $530.00

Specifications

Antigen JAK2
Concentration 0.5 mg/mL
Content And Storage -20°C
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
PIPA5119235
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Invitrogen™
PA5119235
200 μL
Each for $530.00
Only null left
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PIPA5121814
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Invitrogen™
PA5121814
20 μL
Each for $209.50
Only null left
Add to Cart
 
Description

Description

JAK2 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
Specifications

Specifications

JAK2
-20°C
Polyclonal
Liquid
IgG
Human
JAK2
EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2
JAK2
Primary
Antigen Affinity Chromatography
0.5 mg/mL
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Unconjugated
Rabbit
RUO
PBS with 50% glycerol and 0.05% ProClin 300
O60674
3717
Recombinant protein Janus Kinase 2. The antigen corresponds to amino acid range 508-800 of the target protein.
Antibody
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