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Invitrogen™ JAK2 Polyclonal Antibody
Rabbit Polyclonal Antibody
$209.50 - $530.00
Specifications
| Antigen | JAK2 |
|---|---|
| Concentration | 0.5 mg/mL |
| Content And Storage | -20°C |
| Applications | Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|
PIPA5119235
|
Invitrogen™
PA5119235 |
200 μL |
Each for $530.00
|
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PIPA5121814
|
Invitrogen™
PA5121814 |
20 μL |
Each for $209.50
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Description
JAK2 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.Specifications
| JAK2 | |
| -20°C | |
| Polyclonal | |
| Liquid | |
| IgG | |
| Human | |
| JAK2 | |
| EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2 | |
| JAK2 | |
| Primary | |
| Antigen Affinity Chromatography |
| 0.5 mg/mL | |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| PBS with 50% glycerol and 0.05% ProClin 300 | |
| O60674 | |
| 3717 | |
| Recombinant protein Janus Kinase 2. The antigen corresponds to amino acid range 508-800 of the target protein. | |
| Antibody |
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