Invitrogen™ Human JAK2, GST Tag Recombinant Protein

Catalog No. PR7820B

Supplier: Invitrogen™ PR7820B

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Catalytic Domain, Cytoplasmic.

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.

Specifications

• Accession Number: O60674
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris with 50% glycerol, 0.5mM EDTA, 0.02% Triton X-100, 2mM DTT, 150mM NaCl and no preservative; pH 7.5
• Gene ID (Entrez): 3717
• Molecular Weight (g/mol): 66.6 kDa
• Name: Human JAK2, GST Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 100 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2
• Common Name: JAK2
• Gene Symbol: JAK2
• KinaseFamily: JAK Kinase Family
• Protein Length: 809-1153 +9
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: 809-1153 +9
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Kinase Group: Tyrosine Kinases
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Catalytic Domain, Cytoplasmic
• Form: Liquid
• Research Category: Signal Transduction
• Purity or Quality Grade: 95% by SDS-PAGE

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov