Invitrogen™ JAK3 Polyclonal Antibody

Catalog No.	Quantity
PIPA584838	100 μL

Catalog No. PIPA584838

Supplier: Invitrogen™ PA584838

Description

Rabbit Polyclonal Antibody

Immunogen sequence: ETFHVGLPGA LGGHDGLGLL RVAGDGGIAW TQGEQEVLQP FCDFPEIVDI SIKQAPRVGP AGEHRLVTVT RTDNQILEAE FPGL Highest antigen sequence indentity to the following orthologs: Rat - 71%, Mouse - 76%.

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.

Specifications

• Antigen: JAK3
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: JAK3
• Gene Accession No.: P52333
• Gene Alias: Breast-JAK3; fae; JAK3; JAK-3; JAK3_HUMAN; JAK3B; JAKL; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; L JAK; Leukocyte janus kinase; LJAK; L-JAK; RATJAK3; Tyrosine-protein kinase JAK3; wil
• Gene Symbols: JAK3
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human JAK3. Recombinant protein control fragment (Product #RP-104037).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3718
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG