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Invitrogen™ JAM-A (CD321) Polyclonal Antibody
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Catalog No. PIPA547059
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100 μg
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PIPA547059 100 μg
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Catalog No. PIPA547059 Supplier Invitrogen™ Supplier No. PA547059
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Description

Goat Polyclonal Antibody

In sandwich ELISAs, less than 1% cross-reactivity with recombinant human JAM-A, recombinant mouse (rm) JAM-B, and rmJAM-C is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JAM-A (CD321)
Applications ELISA, Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene F11r
Gene Accession No. O88792
Gene Alias 9130004G24; AA638916; BV11 antigen; CD321; ESTM33; F11 R; F11 receptor; F11 receptor/F11R; F11R; JAM; JAM1; JAM-1; JAMA; JAM-A; Jcam; Jcam1; junction cell adhesion molecule A; junction cell adhesion molecule1; junctional adhesion molecule 1; Junctional adhesion molecule A; KAT; Ly106; PAM-1; Platelet adhesion molecule 1; platelet F11 receptor; UNQ264/PRO301
Gene Symbols F11r
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse JAM-A Lys27-Ala242.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16456
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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