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Invitrogen™ JAM-A (CD321) Polyclonal Antibody
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Catalog No. PIPA5120157
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100 μL
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PIPA5120157 100 μL
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Catalog No. PIPA5120157 Supplier Invitrogen™ Supplier No. PA5120157
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Description

Rabbit Polyclonal Antibody

Positive test controls include: HepG2, SKOV3, Mouse lung, Rat lung. The target is usually found in the following locations: Cell junction, Cell membrane, Single-pass type I membrane protein, tight junction. Immunogen sequence: SVTVHSSEPE VRIPENNPVK LSCAYSGFSS PRVEWKFDQG DTTRLVCYNN KITASYEDRV TFLPTGITFK SVTREDTGTY TCMVSEEGGN SYGEVKVKLI VLVPPSKPTV NIPSSATIGN RAVLTCSEQD GSPPSEYTWF KDGIVMPTNP KSTRAFSNSS YVLNPTTGEL VFDPLSASDT GEYSCEARNG YGTPMTSNAV RMEAVERNVG V.

CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.
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Specifications

Antigen JAM-A (CD321)
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 3.85 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene F11r
Gene Accession No. O88792, Q9JHY1, Q9Y624
Gene Alias 9130004G24; AA638916; BV11 antigen; CD321; ESTM33; F11 R; F11 receptor; F11 receptor/F11R; F11R; JAM; JAM1; JAM-1; JAMA; JAM-A; Jcam; Jcam1; junction cell adhesion molecule A; junction cell adhesion molecule1; junctional adhesion molecule 1; Junctional adhesion molecule A; KAT; Ly106; PAM-1; Platelet adhesion molecule 1; platelet F11 receptor; UNQ264/PRO301
Gene Symbols F11r
Host Species Rabbit
Immunogen Recombinant protein (or fragment)
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116479, 16456, 50848
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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