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Invitrogen™ JAML Polyclonal Antibody
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Catalog No. PIPA5114263
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100 μL
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PIPA5114263 100 μL
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Catalog No. PIPA5114263 Supplier Invitrogen™ Supplier No. PA5114263
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VCATILLLPV LILIVKKTCG NKSSVNSTVL VKNTKKTNPE MKEKPCHFER For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Human: 100%.

AMICA transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JAML
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene JAML
Gene Accession No. Q86YT9
Gene Alias adhesion molecule AMICA; adhesion molecule interacting with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; AMICA; Amica1; Crea7; CREA7-1; CREA7-4; Dendritic cell-specific protein CREA7; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein Crea7; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; Gm638; Jaml; junction adhesion molecule like; junctional adhesion molecule-like; mCrea7; UNQ722/PRO1387
Gene Symbols JAML
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal region of human JAML.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 120425
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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