JARID1B Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc IHC00370T

Catalog No. 50-157-1980

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Dog, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon and Smal

KDM5B is a histone demethylase that demethylates ′Lys-4′ of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 ′Lys-9′ or H3 ′Lys-27′. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 ′Lys-4′. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.

Specifications

• Antigen: JARID1B
• Classification: Polyclonal
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Accession No.: Q9UGL1
• Gene Symbols: KDM5B
• Immunogen: Between 1494 and 1544
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry
• Conjugate: Unconjugated
• Gene: KDM5B
• Gene Alias: RBBP2H1A, PLU1, PLU-1, CT31, lysine K-specific demethylase 5B, JARID1B, PUT1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10765
• Content And Storage: 4° C
• Form: Liquid