Invitrogen™ JARID1C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115462

Catalog No. PIPA5115462

Description

Antibody detects endogenous levels of total KDM5C / Jarid1C / SMCX.

Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Specifications

• Antigen: JARID1C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDM5C
• Gene Alias: D930009K15Rik; DXS1272E; Histone demethylase JARID1C; JARID1C; JmjC domain-containing protein SMCX; jumonji, AT rich interactive domain 1C (Rbp2 like); Jumonji, AT rich interactive domain 1C (RBP2-like); Jumonji/ARID domain-containing protein 1C; KDM5C; Kiaa0234; lysine (K)-specific demethylase 5C; lysine demethylase 5C; lysine-specific demethylase 5C; mKIAA0234; MRX13; MRXJ; MRXSCJ; MRXSJ; Protein SmcX; Protein Xe169; RGD1560601; sele; selected mouse cDNA on the X; SMCX; Smcx homolog, X chromosome; Smcy homolog, X-linked; XE169
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20591, 317432, 8242
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P41229, P41230
• Gene Symbols: KDM5C
• Immunogen: A synthesized peptide derived from human KDM5C(Accession P41229), corresponding to amino acid residues L1440-E1490.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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