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Tocris Bioscience™ JB 300
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Catalog No. 78375
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78-375 5 mg
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Catalog No. 78-375 Supplier Tocris Bioscience™ Supplier No. 7837/5
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Description

Aurora A Degrader (PROTAC™;)

JB 300 is a potent and selective Aurora A Degrader (PROTAC™;; DC50 = 30 nM and Dmax = 78%). It comprises a cereblon E3-ligase ligand Thalidomide (Cat. No. 0652) joined by a PEG2 linker to the Aurora A inhibitor MK-5108. The compound depletes Aurora A in MV4-11 cell lines and exhibits no degradation of Aurora B at 10 μM. JB 300 shows dose-dependent cytotoxicity in AML cells .

PROTAC™; is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material trans-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide
Quantity 5 mg
Target Active Degraders
Molecular Formula C43H45ClFN7O10S
Purity 0.98
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