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  5. Tocris Bioscience™ JH-II-127

Tocris Bioscience™ JH-II-127
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Catalog No. 628950
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Catalog No. Quantity
62-895-0 50 mg
62-891-0 10 mg
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Catalog No. 62-895-0 Supplier Tocris Bioscience™ Supplier No. 6289/50
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Description

Potent and selective LRRK2 inhibitor

JH-II-127 is a potent and selective LRRK2 inhibitor (IC50 values are 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively). Selective for LRRK2 over a panel of 138 kinases. Brain penetrant and orally bioavailable.

Specifications

Chemical Name or Material [4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone
CAS 1700693-08-8
Assay Percent Range >98%
Quantity 50 mg
Molecular Formula C19H21ClN6O3
Formula Weight Observed MW: 416.87
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