Invitrogen™ JHDM1D Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552912

Catalog No. PIPA552912

Description

Immunogen sequence: LETLKELRED GFQPQTYLVQ GVKALHTALK LWMKKELVSE HAFEIPDNVR PGHLIKELSK VIRAIEEENG KPVKSQGIPI VCPVSRSSNE A Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 92%.

JHDM1D histone demethylase that specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. This specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. This demethylates H3K9me2 in absence of H3K4me3.

Specifications

• Antigen: JHDM1D
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDM7A
• Gene Alias: A630082K20Rik; BB041802; ENSMUSG00000073143; histone lysine demethylase JHDM1D; Jhdm1d; JmjC domain-containing histone demethylation protein 1D; jumonji C domain containing histone demethylase 1; jumonji C domain containing histone demethylase 1 homolog D; jumonji C domain-containing histone demethylase 1 homolog D; Kdm7; Kdm7a; Kiaa1718; lysine (K)-specific demethylase 7A; lysine demethylase 7A; lysine-specific demethylase 7; Lysine-specific demethylase 7A; mKIAA1718
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80853
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6ZMT4
• Gene Symbols: KDM7A
• Immunogen: Recombinant protein corresponding to Human JHDM1D. Recombinant protein control fragment (Product #RP-89695).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov