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  5. Tocris Bioscience™ JHU 37160

Tocris Bioscience™ JHU 37160
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Catalog No. 719810
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Catalog No. Quantity
71-981-0 10 mg
71-985-0 50 mg
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Catalog No. 71-981-0 Supplier Tocris Bioscience™ Supplier No. 7198/10
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Description

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro, respectively; EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in vitro, respectively). Displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21 (Cat. No. 5548). Selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. Brain penetrant in mice, rats and non-human primates.

Specifications

Chemical Name or Material 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
CAS 2369979-68-8
Quantity 10 mg
Target DREADD Activators
Molecular Formula C19H20ClFN4
Purity 0.98
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