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Tocris Bioscience™ JIB 04

Name: Tocris Bioscience&trade; JIB 04
Brand: Tocris Bioscience&trade;
SKU: 49-725-0R
Price: 1031.24 USD

Pan Jumonji inhibitor; active in vivo

Supplier: Tocris Bioscience™ 4972/50

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Catalog No. 49-725-0R

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Description

JIB 04 is a pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. Prolongs survival in a mouse model of breast cancer.

Specifications

Purity	>99%
Product Type	JIB 04
Inhibitors	JIB 04

Quantity	50 mg
Molecular Weight (g/mol)	308.76

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Tocris Bioscience™ JIB 04

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