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Invitrogen™ JIP1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA526030
Description
JIP1 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow
The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Specifications
JIP1 | |
Polyclonal | |
Unconjugated | |
MAPK8IP1 | |
C-Jun-amino-terminal kinase-interacting protein 1; Ib1; IB-1; Islet-brain 1; islet-brain-1; JIP1; JIP-1; JIP-1-related protein; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; JRP; Mapk8ip; Mapk8ip1; mitogen activated protein kinase 8 interacting protein; mitogen activated protein kinase 8 interacting protein 1; mitogen-activated protein kinase 8 interacting protein 1; mitogen-activated protein kinase 8-interacting protein 1; mjip-2a; PRKM8 interacting protein; PRKM8IP; protein kinase, mitogen-activated 8 interacting protein; Skip | |
Rabbit | |
Antigen affinity chromatography, Protein A | |
RUO | |
9479 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
0.45 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
Q9UQF2 | |
MAPK8IP1 | |
KLH conjugated synthetic peptide between 470-498 amino acids from the C-terminal region of human JIP1. | |
400 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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