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JIP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

$518.60

Specifications

Antigen JIP1
Concentration 0.3 mg/mL
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-172-9548
SDP
Encompass_Preferred
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Proteintech Group Inc
145681AP150UL
150 μL
Each of 1 for $518.60
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Description

Description

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Specifications

Specifications

JIP1
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Rabbit
Human, Mouse, Rat
Q9R237, Q9UQF2, Q9WVI9
116457, 19099, 9479
JIP1 Fusion Protein Ag6150
Primary
-20°C
MAPK8IP1
0.3 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
IB 1, IB1, Islet brain 1, JIP 1, JIP1, JNK interacting protein 1, MAPK8IP1, PRKM8IP
Mapk8ip1
IgG
Antigen Affinity Chromatography
Antibody
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SDS
Documents

Documents

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