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Invitrogen™ JMJD1A Monoclonal Antibody (3G10C2)
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Catalog No. FERMA548763
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100 μg
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Catalog No. Quantity
FERMA548763 100 μg
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Catalog No. FERMA548763 Supplier Invitrogen™ Supplier No. MA548763
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Description

Mouse Monoclonal Antibody

JMJD1A Monoclonal Antibody for Western Blot, ICC/IF, Flow, ELISA

JMJD1A is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. It's also Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JMJD1A
Applications ELISA, Flow Cytometry, Western Blot, Immunocytochemistry, Western Blot
Classification Monoclonal
Clone 3G10C2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene KDM3A
Gene Accession No. Q9Y4C1
Gene Alias 1700105C21Rik; C230043E16Rik; DKFZp686A24246; DKFZp686P07111; JHDM2a; JHMD2A; JmjC domain-containing histone demethylation protein 2A; Jmjd1; Jmjd1a; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1A; jumonji domain-containing protein 1A; KDM2A; Kdm3a; Kiaa0742; lysine (K)-specific demethylase 3A; lysine demethylase 3A; lysine-specific demethylase 3A; probable zinc finger protein; testis specific gene A; testis-specific gene A protein; testis-specific protein A; TGSA; Tsga; zinc finger protein TSGA
Gene Symbols KDM3A
Host Species Mouse
Immunogen Purified recombinant fragment of human KDM3A (AA: 311-445) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55818
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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