Invitrogen™ JMJD1A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588279

Catalog No. PIPA588279

Description

Positive Samples: 293T; Cellular Location: Cytoplasm, Nucleus Immunogen sequence: PVMVSGVHHK LNSELWKPES FRKEFGEQEV DLVNCRTNEI ITGATVGDFW DGFEDVPNRL KNEKEPMVLK LKDWPPGEDF RDMMPSRFDD LMANIPLPEY TRRDGKLNLA SRLPNYFVRP DLGPKMYNAY GLITPEDRKY GTTNLHLDVS DAANVMVYVG IPKGQCEQEE EVLKTIQDGD SDELTIKRFI EGKEKPGALW HIYAAKDTEK IREFLKKVSE EQGQENPADH DPIHDQSWYL DRSLRKRLHQ EYGVQGWAIV QFLGDVVFIP AGAPHQVHNL YSCIKVAEDF VSPEHVKHCF WLTQEFRYL.

JMJD1A is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. It's also Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

Specifications

• Antigen: JMJD1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDM3A
• Gene Alias: 1700105C21Rik; C230043E16Rik; DKFZp686A24246; DKFZp686P07111; JHDM2a; JHMD2A; JmjC domain-containing histone demethylation protein 2A; Jmjd1; Jmjd1a; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1A; jumonji domain-containing protein 1A; KDM2A; Kdm3a; Kiaa0742; lysine (K)-specific demethylase 3A; lysine demethylase 3A; lysine-specific demethylase 3A; probable zinc finger protein; testis specific gene A; testis-specific gene A protein; testis-specific protein A; TGSA; Tsga; zinc finger protein TSGA
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55818
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.88 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q9Y4C1
• Gene Symbols: KDM3A
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 975-1283 of human KDM3A (NP_0609032).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG