Invitrogen™ JMJD1A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578535

Catalog No. PIPA578535

Description

Positive Control: 293T, A431, HeLa, HepG2 Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

JMJD1A is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. It's also Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

Specifications

• Antigen: JMJD1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDM3A
• Gene Alias: 1700105C21Rik; C230043E16Rik; DKFZp686A24246; DKFZp686P07111; JHDM2a; JHMD2A; JmjC domain-containing histone demethylation protein 2A; Jmjd1; Jmjd1a; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1A; jumonji domain-containing protein 1A; KDM2A; Kdm3a; Kiaa0742; lysine (K)-specific demethylase 3A; lysine demethylase 3A; lysine-specific demethylase 3A; probable zinc finger protein; testis specific gene A; testis-specific gene A protein; testis-specific protein A; TGSA; Tsga; zinc finger protein TSGA
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55818
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q9Y4C1
• Gene Symbols: KDM3A
• Immunogen: Recombinant protein encompassing a sequence within the center region of human KDM3A. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG