Invitrogen™ JMJD1C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563258

Catalog No. PIPA563258

Description

Immunogen sequence: PNVSDSKHSI ANAKFLETAK KDSDQSWVSD VVKVDLTQSS VTNASSGNDH LNMEKEKYVS YISPLSAVSV MEDKLHKRSP PPETIKSKLN TSVDTHKIKS SPSPEVVKPK Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 77%.

The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.

Specifications

• Antigen: JMJD1C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: JMJD1C
• Gene Alias: 5430433L24Rik; D630035I23Rik; DKFZp761F0118; FLJ14374; Jhdm2c; JMJD1C; Jmjdic; jumonji domain containing 1C; jumonji domain-containing protein 1C; Kiaa1380; Pr2; Probable JmjC domain-containing histone demethylation protein 2C; RP11-10C13.2; thyroid hormone receptor interactor 8; thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP8; TRIP-8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 221037
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q15652
• Gene Symbols: JMJD1C
• Immunogen: Recombinant protein corresponding to Human JMJD1C. Recombinant protein control fragment (Product #RP-93608).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG