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Invitrogen™ JMJD2D Polyclonal Antibody
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Catalog No. PIPA5100762
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PIPA5100762 100 μL
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Catalog No. PIPA5100762 Supplier Invitrogen™ Supplier No. PA5100762
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total JHD3D.

The JMJD2D gene encodes a member of the Jumonji C domain-containing histone demethylases, which are involved in the epigenetic regulation of gene expression by demethylating lysine residues on histone proteins. JMJD2D specifically interacts with β-catenin and is implicated in colorectal cancer, where it activates transcription of target genes and promotes cell proliferation, migration, and tumor formation. Structurally, JMJD2D belongs to the JMJD2 family but exhibits distinct features, lacking certain regions that make it the most structurally divergent within the family. Additionally, JMJD2D stabilizes and cooperates with the hepatitis B virus protein HBx, facilitating cccDNA transcription by demethylating H3K9me3 and counteracting the repressive effects of p53. JMJD2D's role in various cellular processes highlights its importance in both cancer pathogenesis and viral replication, making it a potential target in therapeutic research for colorectal cancer and hepatitis B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JMJD2D
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene KDM4D
Gene Accession No. A1A5Q5, Q6B0I6
Gene Alias FLJ10251; JHDM3D; JmjC domain-containing histone demethylation protein 3D; JMJD2D; jumonji domain containing 2D; jumonji domain-containing protein 2D; KDM4D; lysine (K)-specific demethylase 4D; lysine demethylase 4D; lysine-specific demethylase 4D
Gene Symbols KDM4D
Host Species Rabbit
Immunogen A synthesized peptide derived from human KDM4D(Accession Q6B0I6), corresponding to amino acid residues M1-M38.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55693, 689582
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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