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Invitrogen™ JMJD3 Polyclonal Antibody
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Catalog No. PIPA532192
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100 μL
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PIPA532192 100 μL
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Catalog No. PIPA532192 Supplier Invitrogen™ Supplier No. PA532192
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A375. Predicted reactivity: Mouse (98%), Rat (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JMJD3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.95 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene KDM6B
Gene Accession No. O15054, Q5NCY0
Gene Alias 1700064E03Rik; BC038313; jmjC domain-containing protein 3; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jumonji domain-containing 3; jumonji domain-containing protein 3; KDM1 lysine (K)-specific demethylase 6B; Kdm6b; KIAA0346; lysine (K)-specific demethylase 6B; lysine demethylase 6B; Lysine-specific demethylase 6B; mKIAA0346
Gene Symbols KDM6B
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the C-terminus region of human JMJD3. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216850, 23135, 363630
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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