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Invitrogen™ JMY Polyclonal Antibody
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Catalog No. PIPA5106460
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100 μL
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PIPA5106460 100 μL
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Catalog No. PIPA5106460 Supplier Invitrogen™ Supplier No. PA5106460
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total JMY.

JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JMY
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene JMY
Gene Accession No. Q8N9B5, Q9QXM1
Gene Alias FLJ37870; JMY; junction mediating and regulatory protein, p53 cofactor; junction-mediating and regulatory protein; junction-mediating and -regulatory protein; LOC683593; p300 transcriptional cofactor JMY; similar to junction-mediating and regulatory protein; WAS protein homology region 2 domain containing 1-like 3; WHAMM2; WHDC1L3
Gene Symbols JMY
Host Species Rabbit
Immunogen A synthesized peptide derived from human JMY(Accession Q8N9B5), corresponding to amino acid residues E945-N988.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 133746, 57748, 683593
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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