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  5. Tocris Bioscience™ JNJ 39758979 Dihydrochloride

Tocris Bioscience™ JNJ 39758979 Dihydrochloride
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Catalog No. 62795
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Quantity:
5 mg
25 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

High affinity and selective histamine H4 antagonist; orally bioavailable

JNJ 39758979 dihydrochloride is a high affinity and selective histamine H4 antagonist (Ki = 12.5 nM). Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.

Specifications

Chemical Name or Material 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride
Quantity 5 mg
Molecular Formula C11H19N5.2HCl
Formula Weight 294.22
Purity 98%
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