Invitrogen™ JNK1/JNK3 Recombinant Rabbit Monoclonal Antibody (JJ08-86)

Catalog No.	Quantity
PIMA532453	100 μL

Catalog No. PIMA532453 Supplier Invitrogen™ Supplier No. MA532453

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Specifications

• Antigen: JNK1/JNK3
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Recombinant Monoclonal
• Clone: JJ08-86
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene: MAPK8
• Gene Accession No.: P45983, P49185, P49187, P53779, Q61831, Q91Y86
• Gene Alias: AI849689; C230008H04Rik; c-Jun N-terminal kinase 1; c-Jun N-terminal kinase 3; JNK; Jnk1; JNK1 beta1 protein kinase; JNK1A2; JNK21B1/2; JNK3; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JNK3A; JNK3B1; JNK3B2; JNK-46; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAP kinase p49 3F12; MAPK 10; MAPK 8; MAPK10; Mapk8; mitogen activated protein kinase 10; mitogen activated protein kinase 8; mitogen-activated protein kinase 10; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; p493F12; p54 gamma; p54-beta; p54bSAPK; PRKM10; Prkm8; protein kinase mitogen-activated 8; SAPb; SAPK gamma; SAPK(beta); SAPK/Erk/kinase 2; SAPK1; SAPK1b; SAPK1c; SAPK-beta; SAPKC; Serk2; stress activated protein kinase beta; stress-activated protein kinase 1; stress-activated protein kinase 1b; Stress-activated protein kinase 1c; stress-activated protein kinase JNK1; Stress-activated protein kinase JNK3
• Gene Symbols: Mapk10, MAPK8
• Host Species: Rabbit
• Immunogen: Recombinant protein within Human JNK1 + JNK3 aa 1-423.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 116554, 25272, 26414, 26419, 5599, 5602
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG