Invitrogen™ JNK2 beta Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142861

Catalog No. PIPA5142861

Description

Additional Information: This antibody is expected to recognize isoforms beta1 and beta 2 (NP_620708.1; NP_620709.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]. MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Specifications

• Antigen: JNK2 beta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mapk9
• Gene Symbols: Mapk9
• Immunogen: Peptide with sequence C-EMVLHKVLFPGRDY.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P45984, Q9WTU6
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 26420, 5601
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid