Invitrogen™ JNK3 Monoclonal Antibody (10E4A4)

Catalog No.	Quantity
PIMA515403	100 μL

Catalog No. PIMA515403 Supplier Invitrogen™ Supplier No. MA515403

Description

Mouse Monoclonal Antibody

MA5-15403 targets MAPK10 in indirect ELISA, IF and WB applications and shows reactivity with Human and mouse samples. The MA5-15403 immunogen is purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli. MA5-15403 detects MAPK10 which has a predicted molecular weight of approximately 53kDa.

MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). MAPK10 is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Specifications

• Antigen: JNK3
• Applications: ELISA, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 10E4A4
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: ascites with 0.03% sodium azide
• Gene: MAPK10
• Gene Accession No.: P53779, Q61831
• Gene Alias: C230008H04Rik; c-Jun N-terminal kinase 3; hypothetical protein LOC569698; jnk3; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JNK3A; JNK3B1; JNK3B2; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; MAPK10; mitogen activated protein kinase 10; mitogen-activated protein kinase 10; OTTHUMP00000161181; OTTHUMP00000161183; OTTHUMP00000218718; p493F12; p54-beta; p54bSAPK; PRKM10; SAPb; SAPK(beta); SAPK/Erk/kinase 2; SAPK1B; SAPK-beta; SAPKC; Serk2; Stress activated protein kinase beta; stress-activated protein kinase 1b; Stress-activated protein kinase JNK3; zgc:123234
• Gene Symbols: MAPK10
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 26414, 5602
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1