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Invitrogen™ JNK3 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5144962
Description
Immunogen sequence: LHFLYYCSEP TLDVKIAFCQ GFDKQVDVSY IAKHYNMSKS KVDNQFYSVE VGD Antigen sequence identity: Mouse 96%; Rat 94%.
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). MAPK10 is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Specifications
JNK3 | |
Polyclonal | |
Unconjugated | |
MAPK10 | |
C230008H04Rik; c-Jun N-terminal kinase 3; hypothetical protein LOC569698; jnk3; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JNK3A; JNK3B1; JNK3B2; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; MAPK10; mitogen activated protein kinase 10; mitogen-activated protein kinase 10; OTTHUMP00000161181; OTTHUMP00000161183; OTTHUMP00000218718; p493F12; p54-beta; p54bSAPK; PRKM10; SAPb; SAPK(beta); SAPK/Erk/kinase 2; SAPK1B; SAPK-beta; SAPKC; Serk2; Stress activated protein kinase beta; stress-activated protein kinase 1b; Stress-activated protein kinase JNK3; zgc:123234 | |
Rabbit | |
Affinity chromatography | |
RUO | |
5602 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid | |
IgG |
Western Blot, Immunocytochemistry | |
0.3 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P53779 | |
MAPK10 | |
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 3-55. | |
100 μL | |
Primary | |
Human | |
Antibody | |
Liquid |
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