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Tocris Bioscience™ JP-2-196 alkyne

Catalog No. 804750
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80-475-0 50 mg
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Catalog No. 80-475-0 Supplier Tocris Bioscience™ Supplier No. 8047/50
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Description

RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046).

JP-2-196 alkyne is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM1. By facilitating E3 ligase recruitment, JP-2-196 alkyne induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders. JP-2-196 alkyne is an alkyne functionalized version of JP-2-196 (Cat. No. 8046).

Specifications

Chemical Name or Material 1-(4-Methoxyphenyl)-4-[4-(2-propyn-1-yl)-1-piperazinyl]-2-butene-1,4-dione
CAS 2901113-25-3
Quantity 50 mg
Target Molecular Glues
Molecular Formula C18H20N2O3
Purity 0.95
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