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JPH2 Mouse anti-Human, Clone: OTI2D3, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF507005

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predomitly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2-null mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.Specifications
JPH2 | |
Monoclonal | |
Unconjugated | |
JPH2 | |
CMH17, JP-2, JP2 | |
Mouse | |
Affinity Chromatography | |
RUO | |
57158 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI2D3 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
Q9BR39 | |
JPH2 | |
Full length human recombit protein of human JPH2 produced in HEK293T cell. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2b |
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