Invitrogen™ JPH4 Polyclonal Antibody

Catalog No.	Quantity
PIPA587818	100 μL

Catalog No. PIPA587818 Supplier Invitrogen™ Supplier No. PA587818

Description

Rabbit Polyclonal Antibody

Immunogen sequence: AARMAKLIAQ DLQPMLEAPG RRPRQDSEGS DTEPLDEDSP GVYENGLTPS EGSPELPSSP ASSRQPWRPP ACRSPLPPGG DQGPFSSPKA WPEEWGGAGA QAEELAGYEA EDEAGMQGPG PRDGSPLLGG CSDSSGSLRE EEGEDEEPLP PLRAPAGTEP EPIAMLVLRG SSSRGPDAGC LTEELGEPAA TERPAQPGAA N; Positive Samples: U-87MG, HT-1080, HepG2, 293T, Mouse liver, Rat brain; Cellular Location: Cell membrane, Endoplasmic reticulum membrane, Peripheral membrane protein, Single-pass type IV membrane protein.

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain. In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions.

Specifications

• Antigen: JPH4
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 2.77 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: JPH4
• Gene Accession No.: Q69FB3, Q80WT0, Q96JJ6
• Gene Alias: 9330157P13Rik; JP4; JP-4; Jph4; jph4 {ECO:0000312; JPHL1; junctophilin 4; junctophilin like 1; junctophilin-4; Junctophilin-like 1 protein; KIAA1831; RGD:1303170}
• Gene Symbols: JPH4
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 405-605 of human JPH4 (NP_1158282).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 319984, 445271, 84502
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG