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(+)-JQ1, Tocris Bioscience™

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Quantity:
10mg
This item is not returnable. View return policy
1268524-70-4
C23H25ClN4O2S
456.989
DNVXATUJJDPFDM-KRWDZBQOSA-N
+-jq-1,+-jq1,jq1 compound,jq-1,unii-1mrh0imx0w,s-tert-butyl 2-4-4-chlorophenyl-2,3,9-trimethyl-6h-thieno 3,2-f 1,2,4 triazolo 4,3-a 1,4 diazepin-6-yl acetate,s-jq1,1mrh0imx0w,jq1,bromodomain inhibitor, +-jq1
46907787
CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
This item is not returnable. View return policy
1268524-70-4
C23H25ClN4O2S
456.989
DNVXATUJJDPFDM-KRWDZBQOSA-N
+-jq-1,+-jq1,jq1 compound,jq-1,unii-1mrh0imx0w,s-tert-butyl 2-4-4-chlorophenyl-2,3,9-trimethyl-6h-thieno 3,2-f 1,2,4 triazolo 4,3-a 1,4 diazepin-6-yl acetate,s-jq1,1mrh0imx0w,jq1,bromodomain inhibitor, +-jq1
46907787
CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C

Potent and selective BET bromodomain inhibitor; cell permeable

Potent, high affinity, selective BET bromodomain inhibitor (IC50 values are 17.7, 32.6, 76.9 and 12942 nM for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively; Kd values are 49, 59.5, 82, 90.1, 128 and 190 nM for BRD4 (N), BRD3 (N), BRD3 (C), BRD4 (C), BRD2 (N) and BRDT (N) respectively). Induces squamous differentiation in NUT midline carcinoma (NMC) cell lines; inhibits tumor growth in NMC xenograft models in vivo. Exhibits reversible contraceptive effects in germ cells from male mice.

Inactive Analog also available.

Carboxylic acid-functionalized (Cat. No. 6588) and click-activated (alkyne) (Cat. No. 6589) versions for PROTAC development also available.

Quantity 10mg
Formula Weight 456.99
Percent Purity >98%
Chemical Name or Material (+)-JQ1

Recommended Storage : Store at -20°C