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Tocris Bioscience™ JQKD 82 dihydrochloride
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Catalog No. 76765 Shop All R&D Systems Products
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76-765 5 mg
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Catalog No. 76-765 Supplier Tocris Bioscience™ Supplier No. 7676/5
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Description

Selective inhibitor of lysine demethylase 5

JQKD 82 dihydrochloride is cell-permeable, selective inhibitor of lysine demethylase 5 (KDM5). JQKD 82 does not show activity toward other KDMs; and it has selectivity for KDM5A over other KDM5 isoforms. JQKD 82 causes hypermethylation of H3K4me3, downregulation of MYC targets and RNAPII phosphorylation; it suppresses multiple myeloma cell (MM.1S) growth (IC50 = 0.42 μmol/L). JQKD 82-treated tumors display an increase in H3K4me3 levels and results in a reduction of MYC immuno-staining in NSG mice.

Specifications

Chemical Name or Material 2,4-Diisopropoxyphenyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate dihydrochloride
Quantity 5 mg
Target Histone Demethylase Inhibitors
Molecular Formula C27H40N4O50.2 HCl
Purity 0.98
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