Invitrogen™ JSRP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560811

Catalog No. PIPA560811

Description

Immunogen sequence: EAEVRPKIPG SREAAENDEE EPGEATGEAV REDRVTLADR GPKERPRREG KPRKEKPRKE ERPKKERPRK EER Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 48%.

The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR and RyR. Another skeletal muscle specific 90 kDa protein has also been localized to the this junction. This protein is phosphorylated by an intrinsic protein kinase in triads suggesting that it may play an important regulatory or structural role in the skeletal muscle triad junction.

Specifications

• Antigen: JSRP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: JSRP1
• Gene Alias: 2300003C06Rik; 2310032K21Rik; homolog of mouse skeletal muscle sarcoplasmic reticulum protein JP-45; JP45; JP-45; Jsrp1; Junctional sarcoplasmic reticulum protein 1; Junctional SR; junctional-face membrane protein of 45 kDa homolog; skeletal muscle sarcoplasmic reticulum protein JP-45
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 126306
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96MG2
• Gene Symbols: JSRP1
• Immunogen: Recombinant protein corresponding to Human JSRP1. Recombinant protein control fragment (Product #RP-99141).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG