Invitrogen™ JTB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587891

Catalog No. PIPA587891

Description

Immunogen sequence: EAPVQEEKLS ASTSNLPCWL VEEFVVAEEC SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL MEQRL; Positive Samples: MCF7, NCI-H460, A375, Rat spleen, Rat thymus; Cellular Location: Cytoplasm, Membrane, Mitochondrion, Single-pass type I membrane protein, centrosome, cytoskeleton, microtubule organizing center, spindle.

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.

Specifications

• Antigen: JTB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: JTB
• Gene Alias: hJT; HJTB; HSPC222; Jtb; jumping translocation breakpoint; jumping translocation breakpoint protein; PAR; PAR protein; Prostate androgen-regulated protein; protein JTB
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10899, 29439
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.51 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O76095, O88823
• Gene Symbols: JTB
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 31-105 of human JTB (NP_0066851).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov