Invitrogen™ Junin mammarenavirus Nucleoprotein Polyclonal Antibody

Catalog No.	Quantity
PIPA5117554	100 μg

Catalog No. PIPA5117554 Supplier Invitrogen™ Supplier No. PA5117554

Description

Rabbit Polyclonal Antibody

This antibody has been tested in direct-ELISA.

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation. Interacts with host IKBKE (via Protein kinase domain); the interaction inhibits IKBKE kinase activity.

Specifications

• Antigen: Junin mammarenavirus Nucleoprotein
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Alias: JUNV; Nucleocapsid protein; Nucleoprotein; Protein N
• Host Species: Rabbit
• Immunogen: Recombinant Junin mammarenavirus Nucleoprotein protein (1-564aa).
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Virus
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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