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Tocris Bioscience™ JW 74
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Catalog No. 565350
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Catalog No. 565350 Supplier Tocris Bioscience™ Supplier No. 5653/50
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Description

Wnt pathway inhibitor

JW 74 is an inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3?/AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. Inhibits tumor growth and formation in mouse models.

Specifications

Chemical Name or Material 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine
CAS 863405-60-1
Quantity 50 mg
Solubility Soluble to 100mM in DMSO
Molecular Formula C24H20N6O2S
Formula Weight Observed MW: 456.52
Purity >99%

For Research Use Only

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