Invitrogen™ K-cadherin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596936

Catalog No. PIPA596936

Description

Immunogen sequence: MRTYRYFLLL FWVGQPYPTL STPLSKRTSG FPAKKRALEL SGNSKNELNR SKRSWMWNQF FLLEEYTGSD YQYVGKLHSD QDRGDGSLKY ILSGDGAGDL FIINENTGDI QATKRLDREE KPVYILRAQA INRRTGRPVE PESEFIIKIH DINDNEPIFT KEVYTATVPE MSDVGTFVVQ VTATDADDPT YGNSAKVVYS ILQGQPYFSV ESETGIIKTA LLNMDRENRE QYQVVIQAKD MGGQMGGLSG; Positive Samples: Mouse kidney, Mouse brain, Rat kidney, Rat brain; Cellular Location: Cell membrane, Single-pass type I membrane protein.

Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4), whereas kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived.

Specifications

• Antigen: K-cadherin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDH6
• Gene Alias: CAD6; CADH6; cadherin 6; cadherin 6, type 2, K-cadherin; cadherin 6, type 2, K-cadherin (fetal kidney); Cadherin6; cadherin-6; Cdh6; k cadherin; KCAD; K-cadherin; Kidney cadherin
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1004, 12563, 25409
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.79 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P55280, P55285, P97326
• Gene Symbols: CDH6
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human K-Cadherin (K-Cadherin (CDH6)) (NP_0049231).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov