Invitrogen™ Kaiso Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA581890

Catalog No. PIPA581890

Description

Immunogen sequence: IAELGVPLSQ VKSISGTAQD GNTEPLPPDS GDKNLVIQKS KDEAQDNGAT IMPIITESFS LSAEDYEMKK IIVTDSDDDD DDVIFCSEIL PTKETLPSNN TVAQVQSNPG PVAISD.

This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensusKAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha 2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

Specifications

• Antigen: Kaiso
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZBTB33
• Gene Alias: AW260253; E130014G12Rik; Kaiso; kaiso transcription factor; RGD1566309; RP23-322E15.9; Transcriptional regulator Kaiso; WUGSC:H_DJ525N14.1; Zbtb33; zinc finger and BTB domain containing 33; zinc finger and BTB domain-containing protein 33; zinc finger transcription factor Kaiso; ZNF348; ZNF-kaiso
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10009
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q86T24
• Gene Symbols: ZBTB33
• Immunogen: Recombinant protein corresponding to Human ZBTB33. Recombinant protein control fragment (Product #RP-91977).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG