Invitrogen™ KAL1 Monoclonal Antibody (OTI5E10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527048

Catalog No. PIMA527048

Description

KAL1 Monoclonal Antibody for IHC (P)

KAL1 (Anosmin-1) an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.

Specifications

• Antigen: KAL1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P23352
• Gene Symbols: ANOS1
• Immunogen: Human recombinant protein fragment corresponding to amino acids 129-373 of KAL1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin)
• Clone: OTI5E10
• Conjugate: Unconjugated
• Gene: ANOS1
• Gene Alias: Adhesion molecule-like X-linked; ADMLX; ANOS1; anosmin; anosmin 1; Anosmin1; anosmin-1; HH1; HHA; KAL; KAL1; KALIG1; KALIG-1; Kallmann syndrome interval gene 1; kallmann syndrome protein; Kallmann syndrome-1 sequence (anosmin-1); KMS; WAP four-disulfide core domain 19; WFDC19
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3730
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid