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Invitrogen™ Kalirin Polyclonal Antibody
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Catalog No. PIPA599843
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PIPA599843 100 μL
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Catalog No. PIPA599843 Supplier Invitrogen™ Supplier No. PA599843
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total KALRN.

HAP1 (huntingtin-associated protein 1) binds to huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington's disease (HD). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons. Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kalirin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene KALRN
Gene Accession No. A2CG49, O60229, P97924
Gene Alias 2210407G14Rik; ARHGEF24; AV235988; CHD5; CHDS5; cyclin B1; DUET; DUO; E530005C20Rik; FLJ12332; FLJ16443; FLJ18196; FLJ18623; Gm539; HAPIP; hCG_2022551; huntingtin-associated protein interacting protein (duo); huntingtin-associated protein-interacting protein; Kalirin; kalirin, RhoGEF kinase; kalrn; PAM COOH-terminal interactor protein 10; P-CIP10; Protein Duo; RhoGEF kinase; serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine kinase with Dbl- and pleckstrin homology domains; serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; TRAD
Gene Symbols KALRN
Host Species Rabbit
Immunogen A synthesized peptide derived from human KALRN(Accession O60229), corresponding to amino acid residues F1657-C1707.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 545156, 84009, 8997
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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