Invitrogen™ Kallikrein 8 Monoclonal Antibody (369910)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA524112

Catalog No. PIMA524112

Description

In direct ELISAs, no cross-reactivity with recombinant human (rh) UPA-1, rhKallikrein 1, 2, 3, 4, 5, 7, 9, 10, 11, 12, 13, 14, 15, rhKallikrein B1, rhHGFA, rhFactor VII, rhFactor X, rhFactor XI, rhProc, or rhThrombin is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: Kallikrein 8
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O60259
• Gene Symbols: KLK8
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Kallikrein 8/Neuropsin Gln29-Gly260 (predicted).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Neutralization
• Clone: 369910
• Conjugate: Unconjugated
• Gene: KLK8
• Gene Alias: brain serine protease 1; BSP1; EGK_10950; H NRPN; hK8; HNP; kallikrein 8; kallikrein 8 (neuropsin/ovasin); kallikrein related peptidase 8; kallikrein related-peptidase 8; Kallikrein8; kallikrein-8; kallikrein-related peptidase 8; Klk8; mK8; neuropsin; NP; Nrpn; Ovasin; PRO322; protease, serine, 19 (neuropsin); Prss19; Serine protease 19; serine protease TADG-14; TADG14; Tumor-associated differentially expressed gene 14 protein; UNQ283; UNQ283/PRO322
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 11202
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized