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Invitrogen™ Kanamycin Polyclonal Antibody
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Catalog No. PIPA175225
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PIPA175225 1 mg
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Catalog No. PIPA175225 Supplier Invitrogen™ Supplier No. PA175225
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Description

Sheep Polyclonal Antibody

Working Concentration: 0.3125 μg/mL. Sensitivity: 10 ng/mL Kanamycin produces 57% inhibition in a competitive ELISA employing Kanamycin polyclonal antibody.

Kanamycin is only found in individuals that have used or taken this drug. It is an antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components. [PubChem]Aminoglycosides like kanamycin irreversibly bind to specific 30S-subunit proteins and 16S rRNA. Specifically Kanamycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes. [National Center for Biotechnology Information. PubChem Compound Database; CID=6032].
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kanamycin
Applications ELISA
Classification Polyclonal
Concentration 14.042 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Alias C18H36N4O11; Kanamicina; Kanamycin A; Kanamycin Base; Kanamycinum
Host Species Sheep
Immunogen Kanamycin-BTG.
Purification Method Purified
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
Target Molecule Chemical
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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